果冻传媒

When postdoc and professor Patricia Dankers made plans in 2021 to turn their scientific knowledge about regenerating the body鈥檚 own tissue into a business, she had no idea what was about to come her way. All she knew was that she wanted to bring her biomedical research to society, and to do something tangible with it to help people. 

A doctor is what Wu wanted to be as a child. Or an entrepreneur. Or something in the sciences anyway. After some hesitation this Eindhoven native eventually chose 果冻传媒. 鈥淚 was good at engineering in high school. Tinkering and fiddling, doing calculations with levers, I liked that.鈥�

Childhood dream

At the Department of Biomedical Engineering at 果冻传媒, she found everything to set her pulse beating faster: researching medical innovations that can help patients and make an impact. And the opportunity to be an entrepreneur. 鈥淪ince my childhood, I have dreamed of helping patients with my inventions. Now, that is what I call impact from your research. And I鈥檓 going to make that happen!鈥�

Grandmother with kidney disease

鈥淢y grandmother always encouraged me to pursue medical studies. She became ill and passed away when I started the bachelor鈥檚 degree in Biomedical Engineering. She had kidney disease and had to be on dialysis for years. I was angry at the world: why can we send a rocket to the moon, but not figure out how to cure my grandmother?鈥�

鈥淲hen I met Patricia Dankers in my undergraduate phase, she was working on regenerating an artificial kidney with the body鈥檚 own tissue. Her research proved to be very attractive to me. I immediately knew 鈥榮he鈥檚 the one with whom I want to work and graduate鈥�.鈥�

This is exactly what happened, and Wu followed it with a PhD program. 鈥淚 was allowed to conceive and design my own research. I wanted to do something with biomaterials, chemistry, 3D printing, and tissue generation.鈥�

Fan

The icing on the cake for Wu was getting both Dankers and Carlijn Bouten as mentors. 鈥淢y two great female role models! I had been a fan of both of them since my bachelor phase.鈥� After the PhD, a postdoc in Patricia Dankers鈥� group followed. And now Dankers and Wu have joined forces in their startup VivArt-X.

I thought after my master鈥檚 I would deliver a product that helps people. I soon found out that it doesn鈥檛 work that way in academia.

Dan Jing Wu

鈥淚 thought at the beginning of my studies in Biomedical Engineering that in my master鈥檚 I would be able to deliver a product that helps people.鈥� She now laughs at the naivet茅 and ambition of her younger self. 鈥淚 soon found out that academia doesn鈥檛 work like that. You research things and write papers on them, but don鈥檛 develop a product that gets to patients.鈥�

And that鈥檚 the nub of the problem for Dan Jing. 鈥淚t鈥檚 a real shame, isn鈥檛 it, that all this cool research done at 果冻传媒 and other universities fails to get to society?  At least I thought so. That鈥檚 why it鈥檚 so great that I now have the opportunity to do something about it.鈥�

Half the circus passes by in conversation with Dan Jing Wu. She is SO driven and impatient and wants to move forward with VivArt-X, preferably yesterday. Practice is often more uncontrollable, and sometimes makes her a little rebellious. 鈥淚 feel like a puppy who only wants one thing: to run, run, run. But I鈥檓 stuck on a leash that鈥檚 holding me back.鈥�

鈥淚鈥檓 a fixer, a doer.鈥� This was evident when she and a childhood friend started the bag line during her PhD period at 果冻传媒. 鈥淚 found it terrifying, because we put all our savings into it and had no idea whether it would succeed. But we wanted to do it, and learned an enormous amount from it. For me, the nice thing about entrepreneurship, in comparison to doing scientific research, is the speed.鈥�

With startup Vivart-X, her drive to keep that speed up will be sorely tested. The experience of setting up and running a successful bag line does not compare to setting up VivArt-X.

鈥淲ith Noya Noir, I was the investor myself, and helped determine the path we took. Now, we are dealing with shareholders who put money into our idea and who also have their desires.鈥�

Money money money

Money. This simple little word is the burning centerpiece in Wu鈥檚 ambition to improve aftercare for women with breast cancer. That's because you can have a fantastic, scientifically validated idea that you want to bring to market to help as many people as possible. But it鈥檚 not that simple.

鈥淚 thought after my PhD, 鈥業 can start a company from scratch, and I can do research. How hard can it be to set up a startup in medical technology?鈥欌�� That now causes her to laugh out loud.

Leaving the nest

鈥淭here is so much more to it: developing a business plan, finding investors, writing grants, making strategic plans, finding partners for collaborations within consortia, and reading up on laws and regulations.鈥� And everywhere that five-letter word reappears as a prerequisite to making everything happen.

鈥淎s soon as we get funding, I will leave the 果冻传媒 nest and I can give myself a small salary. In addition, we need scientists who will work on the product. That will soon amount to a few hundred thousand euros for salaries, disability insurance, and all the costs associated with having employees. But you also have to think about renting laboratories, the cost of materials, and the approval process for applying our product in the human body. That is a costly, intensive, and lengthy process. And we鈥檙e only talking in thousands.鈥�

Salaries, renting labs, materials, approval of our invention - everything costs money. And we鈥檙e only talking in thousands.

Dan Jing Wu

Wu is happy with the support that they have received from the Brainport region. For example, very early on, she got noticed by the Brabant Development Corporation (). 鈥淎 very good experienced venture builder, Stephan Hulsbergen works there, and he helped me so much. He immediately believed in our idea for VivArt-X and is always there for me when I have questions or doubts.鈥�

鈥淭he BOM currently supports seven companies all working on the topic of breast cancer. One does something with diagnostics, and another with surgery. And we are working on regenerative medicine.鈥�

鈥淭hey give me advice where needed, and help me find investors. They match the amount we manage to bring in. We have come this far in part thanks to BOM. You can鈥檛 do it on your own, you just need that extra push, and that鈥檚 what they give us.鈥�

During the celebration for International Women鈥檚 Day at 果冻传媒, Dan Jing tells a room filled with women about VivArt-X and her ambitions. She smoothly takes her audience through her research on tissue regeneration, and how she wants to use it to help women after breast cancer.

鈥淗ow long will it be before this can actually be applied?鈥� comes the question from the audience. 鈥淚t will definitely be another ten years or so before our invention can really start helping women. And I鈥檓 talking about the best case scenario where we can work hard towards our goal with a large team and enough investors.鈥�

Volumes of thousands of pages

Such a long period does not deter her. 鈥淚t鈥檚 not so simple as first doing a test in vitro, and then testing it on humans the day after. If you want to bring a product to market that will be used in humans, a lot of research is needed. That has to be done safely, properly, and ethically. When you sterilize a device, it can change something. Does something cause irritation or infection? You have to study it all and be able to rule everything out.鈥�

鈥淲e still have so much to research and document. That will result in volumes of thousands of pages to show that we have conducted our investigations through the proper standards.鈥�

I break everything down into small chunks, otherwise you can鈥檛 last the distance.

Dan Jing Wu

Meanwhile, she welcomes small successes, such as founding VivArt-X, or securing funding. 鈥淚 break everything down into chunks, otherwise you can鈥檛 last the distance. First I want to expand the team. Then I work toward the proof of concept - proving that our idea works. Then we鈥檙e one or two years down the line.鈥�

The money also comes in bit by bit. 鈥淚 hustle and scrounge up money everywhere, but it also flies out again. I can raise a thousand euros somewhere, but that鈥檚 already gone after a three-hour conversation with my IP lawyer. Not to mention applying for a patent.鈥�

Collaborating with 果冻传媒

The first bulk of the money she gets from the investment application is to hire staff and conduct all the preclinical studies.

鈥淭he end of May is the deadline for a large European grant to which I will apply, along with a consortium including my old Department of Biomedical Engineering and the Smart BioMaterial Consortium. We do the product development, they provide the facilities, accelerated development and quality control.鈥� This application is worth 1.4 million euros.

Indispensable: mentors

With all the new things she encounters, Wu benefits tremendously from her mentors. 鈥淏eing able to learn from people with so much experience and a huge network is of huge value to me.鈥�

Wu鈥檚 list of mentors has now expanded from BME professors Patricia Dankers and Carlijn Bouten to include e/MTIC director Carmen van Vilsteren, Katja Pahnke, and professor and serial tech entrepreneur Maarten Steinbuch.

Don鈥檛 stray

鈥淐armen supports women entrepreneurs and is in the healthcare corner as director of e/MTIC and chair of TopTeam Top Sector Life Science and Health in the Netherlands. She has a valuable network for me. With Katja I spar a lot about leadership because of her vast experiences. For example, she was named FRITS top woman of the year. Maarten has set up so many companies, also together with the university, I have benefited a lot from talking to him. For example, he gives me tips on how to arrange everything properly around incorporation and personnel. And he also makes sure I don鈥檛 stray from the path.鈥�

I don鈥檛 know if my mentors realize how much they mean to me. A small moment of contact can get me back in the right frame of mind.

Dan Jing Wu

鈥淚f there鈥檚 anything, all I have to do is call or app. They give me lots of concrete tips - 鈥業 would do this or that鈥� or 鈥榞ive him or her a call鈥�. And then I can move on. I don鈥檛 know if they realize how much they are helping me with this. Such a small moment of contact can get me back in the right frame of mind.鈥�

Hiring staff

She is looking forward to hiring the first of her staff at VivArt-X. 鈥淚 have two people ready to be employed as soon as we have the money to do so. These are good scientists, PhDs who are now in Patricia鈥檚 group.鈥�

鈥淓ventually, I want to grow towards a company with four or five employees, so I can also outsource some things. Two researchers who can develop the technology while I take care of investors and all the peripheral issues. And with that money we can then make strides again with the research.鈥�

Entrepreneurship is in Wu鈥檚 blood. 鈥淚 come from a family of entrepreneurs. My parents own several catering businesses. My grandfather used to say to me 鈥榊ou can鈥檛 say something can鈥檛 be done if you haven鈥檛 tried it.鈥欌��

She unmistakably inherited her irrepressible energy and drive for entrepreneurship from them. Studying, pursuing a PhD, and living a life in the service of science is something she got from herself. 鈥淚 do talk to my parents about what I do, but the content is a bit beyond them. What I learned mainly from them is that you should always think in terms of possibilities. At 果冻传媒, I learned how to solve problems as an engineer.鈥�

After being named one of the 50 by the Dutch newspaper Het Financieele Dagblad, Wu was also named winner of the 2023 in May. She ticked all the boxes: woman, Asian, smart, articulate, and working on an innovative idea. 鈥淢y parents first read about their daughter in the media in their own language after winning this award. Only then did I notice their pride in what I have already accomplished.鈥�

Wu's parents are from China. "I feel Dutch, but people don鈥檛 always see me that way. It鈥檚 sometimes a struggle to grow up between two cultures; you don鈥檛 really belong anywhere. In the Netherlands, people see me as Asian, and in China, they see at a glance that I am foreign.鈥�

I can complain about setbacks, but they come with the territory. My parents know that better than anyone with the hospitality business and two lockdowns during the corona crisis. You always have to keep thinking in possibilities.

Dan Jing Wu

Sowing in summer

We鈥檙e in touch via Whatsapp at the end of May: 鈥�I鈥檓 leaving Saturday on a trade mission to Boston with a Dutch delegation of startups in healthcare and life sciences. We are going to a conference and of course to network for ViVart-X. Then I鈥檓 going to spend three weeks doing a full-time animal science course in Utrecht. Once I get that certificate, we will be allowed to set up animal experiments and be present at their implementation. If you鈥檙e not there, you can鈥檛 tell if anything goes wrong. And it鈥檚 good to know more about it, also from an ethical point of view.鈥�

In passing, she reports that the application for the major European grant has been submitted. In addition, agreements with major funders continue unabated, and she is busy expanding the VivArt-X team.

A lot has happened in four months. VivArt-X has now moved into a space in start-up hub Alpha on the 果冻传媒 campus. Wu rents lab space from 果冻传媒.

VivArt-X has now doubled to four employees. Pre-clinical researcher Annika Vrehen and Muhabbat Komil, who specializes in polymer chemistry, have joined the team. 鈥淭hey started with literature research, and they will then go into the lab. I spent a long time working on the plan of how we will approach the research.鈥�

First-timer

鈥淚 am extremely proud of Annika and Muhabbat. They make a valuable contribution. We really do this as a team, and with a common goal. I hope I can keep them motivated - and that they like me. I told them honestly that this is my first time in charge and that we have to help each other. I am eager to learn. That鈥檚 how you go from being a researcher to suddenly becoming a manager. And you have to know everything about HR, finance, insurance, and marcom (marketing communications). And, I鈥檓 also a coffee lady,鈥� Wu jokes.

Prices and awards

It seems like all eyes are suddenly on Wu and VivArt-X. Almost everything she touches seems to succeed. 鈥淲e applied for eight grants and got them all awarded,鈥� she says happily.

There were also plenty of awards and nominations: in August, VivArt-X was named one of the ten most promising startups in the Brainport region. For this they received the .

In September, they won the from the European Supplier Diversity Projects. VivArt-X finished in the top-3 of the most promising Brabant startups at the , from BOM, Braventure, and The Gate. Wu managed to haul in a total of 12,500 euros in award money.

鈥淲hen I look back at myself a year ago, I do see that I have grown tremendously. I learned a lot, was able to expand my network enormously in the Brainport region, as well as in the life sciences and healthcare sector. I know which programs you can participate in, who the investors are. I鈥檝e learned that the world depends on networking.鈥�

The secret

In turn, she is now trying to help others. 鈥淚 also like to share my knowledge and network, and I鈥檓 doing that now for a few young startups. They sometimes ask what my secret is. I don鈥檛 know that either. Just get to grips with everything, and do it - don鈥檛 hesitate too long.鈥�

The world depends on networking.

Dan Jing Wu

The trade mission Wu was able to join to the United States in June greatly expanded her network in life sciences and healthcare. 鈥淭ogether with other entrepreneurs from startups in my field, I got to take a look at how the biotech and medtech world works in America. We got to look around big companies.鈥�

鈥淚t was such an inspiring trip. I do talk to people in our field in the Netherlands at conferences, but now you sometimes sit next to each other on the bus for hours. That鈥檚 how ideas for future partnerships are easily generated.鈥�

November is the month of big hits: VivArt-X closes the first round of funding with euros. And Wu is awarded the large European Stimulus Grant of 1.4 million euros that she submitted before the vacations with the aforementioned consortium.

鈥淏y the way, that doesn鈥檛 mean we will get 1.4 million cash,鈥� Wu points out. 鈥淔ifty percent of the cost will be borne by the cooperating partners. 35 percent comes from the European grant program OPZuid. The province of North Brabant is signing up for the remaining 15 percent.鈥�

Two years ahead

Together with the award money, previously secured grants, and the money from the first round of investment, Wu has a financial buffer to move forward with VivArt-X for two years.

鈥淭hat鈥檚 such a nice feeling. After being outwardly focused all this time with events, pitches, grant writing, and conversations with investors, I can now turn the focus inward. We are busy further developing the technology to be able to help women in the future.鈥�