PhD research on the challenges and strategic solutions for entrepreneurs to commercialize emerging health technologies

From Opportunity to a Viable Business Model

22 april 2025

René Unteregger's research reveals how health tech entrepreneurs effectively navigate through uncertainties to arrive at viable business models

Photo: Bogdanhoda on iStock

Valley of Death

The commercialization of health technologies is of great importance to society. Innovations in this sector can save lives, improve the quality of care, and increase the efficiency of healthcare systems. However, the path to success is fraught with challenges, such as the long and deep "valley of death" where many innovations fail before reaching the market.

Challenges for Entrepreneurs

Unteregger's research highlights various challenges faced by entrepreneurs in the health tech sector. One example are the difficulties in aligning business models with rapidly evolving health technologies, including issues with intellectual property, clinical validation, reimbursement, and the dependence on venture capitalists, as described by Lehoux et al. (2014). The fast pace of advancement in healthcare—from AI and machine learning to personalized medicine and digital therapeutics—adds another layer of complexity. Additionally, Beaulieu & Lehoux (2018) point to the increasing regulation and institutionalization of health technologies that puts pressure on entrepreneurs to manage conflicting agendas while also building trust and credibility with key stakeholders.

Core Challenges

Unteregger's research shows that navigating these uncertainties requires methods that emphasize rapid learning cycles, resource efficiency, and an intense focus on validating assumptions. The Lean Startup model, introduced by Ries (2011), provides a framework for this approach. The research is structured around three core challenges: complex problem-solving, designing value propositions, and legitimacy-building.

The first study examines how participants in an innovation contest on biosensors shape their problem-solving processes to achieve commercially viable outcomes. The second study introduces a new framework for customer value propositions that accounts for the dynamics of changing customer markets. The third study investigates strategies that technology companies use to overcome legitimation obstacles for non-conventional health technologies.

Interaction and Alignment

Unteregger's research offers concrete actions for entrepreneurs to navigate through uncertainties and develop viable business models. It emphasizes the importance of interaction and alignment with various stakeholders as a crucial strategic activity. These insights help entrepreneurs to convince, engage with, and mobilize key stakeholders such as customers and healthcare professionals.

René Unteregger defended his thesis on April 17, 2025. Title of the thesis: ‘’. Supervisors: Isabelle Reymen, Annelies Bobelyn, and Johanna Höffken.

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