Research Lab

Biomaterial Engineering & Biofabrication

The Biomaterial Engineering and Biofabrication (BEB) laboratory is a multidisciplinary facility within the Regenerative Engineering & Materials cluster at the Department of Biomedical Engineering, 果冻传媒. BEB鈥檚 mission is to invent, model and develop novel biomaterial compositions and (bio)manufacturing processes to engineer predictive in vitro models and implantable functional biomaterials and tissues. The laboratory serves as a breeding ground for research, education, and translation in the field of biomaterial engineering and biofabrication.

Our goal is to improve the diagnosis, treatment, and cure of life-disabling and life-threatening diseases, thereby addressing key societal challenges in healthcare

BIOMATERIALS-BY-DESIGN

The design and manufacturing space for biomaterials and tissues is vast, yet current approaches often rely on trial-and-error methods, rigid line-by-line execution in manufacturing programming languages, and fail to account for process constraints. To overcome these challenges, we integrate computational multi-scale modeling with a manufacturing-specific programming language tailored to our in-house additive manufacturing processes. This enables us to engineer advanced functional materials and devices while ensuring rapid, scalable, and reproducible fabrication.

 

Pioneering Advanced Manufacturing Technologies

Explore our technologies that drive precision, scalability, and autonomous manufacturing. We pioneer multiscale additive manufacturing techniques, focusing primarily on extrusion-based, electrowriting, and volumetric light-based processes. Additionally, to improve manufacturing scalability and autonomy, while gaining deeper insights into biomaterial structure and properties across multiple length and time scales, we integrate in-situ monitoring and advanced materials analysis techniques. These include spectroscopy and high-resolution microscopy, combined with machine learning (ML) and deep learning methods.

 

Bioprinting: where biology and biomaterials fuse

Living tissues exhibit complex 3D structures and multicellular compositions, making them challenging to replicate in tissue-engineered devices. To address this, we innovate and develop our own bioinks, resins, and biofabrication technologies to recreate biologically relevant environments. We evaluate these bioinks, resins, and bioprinting technologies with various cell sources and organoids, aiming to advance predictive in vitro models and facilitate clinical translation.

 

Creating value through knowledge transfer

We are committed to translating research into real-world applications and contributing to Eindhoven's development as an international biomaterials cluster. Through strategic and unique collaborations with Brainport industries and strategic partners such as Smart Biomaterials Consortium, High-Tech Campus Eindhoven, De Brabantse Ontwikkelings Maatschappij,  Fontys University of Applied Sciences, and the Helmond Biotech Materials Hub within the Brainport region, we bridge the gap between fundamental research and tangible applications. Additionally, we are dedicated to educating the next generation of students in tissue engineering and regenerative medicine, ensuring continued growth and innovation in these critical fields. Our vision extends beyond the laboratory, aiming to create meaningful solutions that will reshape healthcare and beyond.

Meet some of our Researchers

Associate Professor

Miguel Dias Castilho

Doctoral Candidate

Marcela Garc铆a Jim茅nez

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